Among the investigated proangiogenic genes, we also observed decreased expression of PlGF. Rolny et al. [35] demonstrated that inhibition of tumor growth and metastasis results from the induction of polarization of macrophages and normalization of vessels by downregulation of PlGF. In summary, our data demonstrates the shift of the phenotype of tumor-infiltrating cells towards the anti-tumor M1-like phenotype. The gene discussed is PGF; the disease is neoplasm.