Accordingly, although IFN-DCs from both infected cohorts shared a down-modulation of the same functional genes, the degree of such alteration was significantly different in TB-DCs, displaying highly compromised expression of selected genes, also implicated in DC activation and Ag presentation such as IRF4, CD80, CD1a and CD1c (S2 Table, S4 Fig). The gene discussed is IRF4; the disease is tuberculosis.