The region of human Cdc73 (also called parafibromin) responsible for Paf1 complex binding [29] is in a region that is similar to the central 105 amino acid region in S. cerevisiae Cdc73 identified here, and at least some mutant versions of human Cdc73 seen in parathyroid carcinomas have lost their ability to interact with the Paf1 complex [101]. The gene discussed is PAF1; the disease is parathyroid gland carcinoma.