CDC73 and Nephroblastoma: Our results suggest that the CDC73 mutations seen in sporadic and hereditary parathyroid carcinomas and the CTR9 mutations found in Wilms tumor could cause increased genome instability; however, it is not currently known if these defects in human CDC73 and CTR9 cause genome instability and telomere dysfunction in human cells as observed here for the S. cerevisiae cdc73Δ mutation.