FBXW7 encodes an F-box protein and part of the ubiquitin protein ligase SKP1-cullin-F-box (SCF) complex that negatively regulates cyclin E, c-MYC, and notch1 proteins, of which cyclin E has been shown to be a specific marker in basal-like breast cancer [47]. Here, CACUL1 is linked to breast carcinoma.