FBXW7 encodes an F-box protein and part of the ubiquitin protein ligase SKP1-cullin-F-box (SCF) complex that negatively regulates cyclin E, c-MYC, and notch1 proteins, of which cyclin E has been shown to be a specific marker in basal-like breast cancer [47]. The gene discussed is FBXW7; the disease is breast cancer.