EGFR and breast carcinoma: Furthermore, (+)-aeroplysinin-1 from sponge displays a strong antitumor effect by blocking the proliferation of EGFR-dependent human breast cancer cell lines MCF-7 and ZR-75-1 [121], while curcuphenol displays a SRC protein kinase inhibition and curcudiola focal adhesion kinase (FAK) inhibition [122].