We constructed four signal-connectors (Supplementary file 14, 15, 16 and 17) recognizing NF-kB (p65) (ursterWurster and Maher, 2008) to activate two tumor suppressors, Bax (R37) and p21 (R38), and to repress two tumor promoters, Bcl2 (R39) and c-myc (R40), in human bladder cancer T24 cells which normally expressed high levels of NF-kB signals (Figure 6A). The gene discussed is BAX; the disease is urinary bladder cancer.