Rainero et al. (2010) found that the rs1126671 located in exon 7 of the ADH4 gene was associated with an increased risk for CH in Italian case-control study, and the carriers with homozygous rs1126671 AA genotype had more than 2-fold CH risk than those with GG/GA genotypes (OR = 2.33, 95% CI = 1.25 4.37, P = 0.006) [23]. The gene discussed is ADH4; the disease is cyclic hematopoiesis.