IL10 and neoplasm: In contrast, when there is a chronic activation of immune response without resolution of the damaged tissue, accumulation of regulatory T (Treg) cells, Th2 cells, and activated B cells is induced; all these cells secrete protumorigenesis factors (e.g., IL-4, IL-6, IL-10, IL-13, and transforming growth factor (TGF)-beta) that enhances protumorigenesis responses in innate immune cells and inactivate CTL cytotoxicity, thus favoring tumor promotion [3].