Therefore, the reason for using a serum of a primary Sjögren's syndrome with CCP antibody and positive for anti-Ro60 and anti-La antibodies, as well as the lack of commercial antibodies against citrullinated nonhistone proteins, encouraged us to purify CCP antibodies to identify possible areas of citrulination in parotids of Balb/c mice, since the human CCP antibodies have been successfully used by others for tissue labelling [40]. This evidence concerns the gene SSB and Sjogren syndrome.