In this study, the expression levels of P-gp and MRP1 in peripheral blood of patients with refractory epilepsy, general epilepsy and normal subjects showed that the levels in patients with refractory epilepsy were significantly higher than those in patients with general epilepsy and normal subjects, which are consistent with the findings of previous study (16) about the expression levels of P-gp and MRP1 in brain tissues. This evidence concerns the gene PGP and epilepsy.