While our findings could indicate that loss of TSPO expression could play a role in the tumorigenesis of this case of adrenocortical oncocytic neoplasm potentially related to defective steroid biosynthesis, additional studies including a larger number of cases of AON are necessary to validate these findings and to determine the role of TSPO in the pathogenesis of adrenocortical neoplasms including AON. The gene discussed is TSPO; the disease is adrenal cortex neoplasm.