These changes of the transport kinetics and the accumulation of neurotoxins species should take in the study of the pathogenesis of neurodegenerative diseases, where dysfunction of ABCB1 has been associated with Parkinson's disease (PD), progressive supranuclear palsy (PSP), multisystem atrophy (MSA), and with depressive disorders [82–85]. The gene discussed is ABCB1; the disease is multiple system atrophy.