On the other hand, other authors [31] have reported that anti-CD20 and IL-10 treatment in NOD mice can modulate the immune functions by upregulating GATA-3 and IL-4 expression and downregulating T-bet and IFN-γ expression, which are involved in the pathogenesis of T1D, confirming the protective role of IL-10 in T1D. This evidence concerns the gene IL4 and type 1 diabetes mellitus.