When subjects were categorized according to severity of obesity, a higher level of MMP-7 was observed in morbidly obese subjects carrying the -181G variant (AG+GG: 0.32 (0.31–0.6), AA: 0.18 (0.17–0.24), P = 0.01, Pc = 0.04). The gene discussed is MMP7; the disease is obesity due to melanocortin 4 receptor deficiency.