The goals of the current report were to explore the impact of MMP-1 (-519A/G; -1607 1G/2G), MMP-3 Lys45Glu (A/G), MMP-7 -181A/G, and MMP-12 -82A/G SNPs on the development of obesity and its severity among Tunisians. This evidence concerns the gene MMP3 and obesity due to melanocortin 4 receptor deficiency.