The aims of the current study were, therefore, to assess the impact of MMP-1-519A/G (rs1144393), MMP-1 -1607 1G/2G (rs1799750), MMP-3Lys45Glu (A/G) (rs679620), MMP-7 -181A/G (rs11568818), and MMP-12 -82A/G (rs2276109) polymorphisms on obesity status and its anthropometric indicators. The gene discussed is MMP7; the disease is obesity due to melanocortin 4 receptor deficiency.