These results contrast with data from Huang et al. [26] showing that the relationship between the -1607 1G/2G SNP and MMP-1 levels in a Taiwanese population was dependent on obesity status and that obese subjects carrying the 2G/2G genotype had lower MMP-1 levels compared to 1G/1G-carrying individuals. This evidence concerns the gene MMP1 and obesity due to melanocortin 4 receptor deficiency.