AR and Familial prostate cancer: This prostate-cancer derived cell line expresses a single copy of AR, resolved as a single species by western blot (Supplementary Fig. S1), and reproduces several key aspects of AR-driven prostate cancer disease, such as phenotypic responses to stimulation with the AR agonist α-Dihydrotestosterone (DHT) as well as treatment with AR antagonists such as Enzalutamide23.