Furthermore, combination of SEP and αPD-L1 significantly increase IFN-γ and IL-2 levels compared with SEP (each cytokine P < 0.05, respectively, n = 6) or αPD-L1 (each cytokine P < 0.05, respectively, n = 6) in tumor (Fig. 5B,D). The gene discussed is IL2; the disease is neoplasm.