Although IMIG (International Mesothelioma Interest Group) recommended Calretinin, D2–40 (podoplanin), WT1 as mesothelioma markers, CEA, TTF-1, Napsin-A, as lung adenocarcinoma markers, and p63, p40, MOC-31 as for lung squamous carcinoma markers4, the additional immunohistochemical markers will surely benefit in some unusual cases. The gene discussed is NAPSA; the disease is lung adenocarcinoma.