Moreover, in A129 mice, ZIKV infection significantly induces IL-1β production in the brain, spleen, liver and kidney, but such inductions are significantly suppressed by the caspase-1 inhibitor (Ac-YVAD-cmk), confirming that Casp-1 is required for ZIKV-induced activation IL-1β. The gene discussed is CASP1; the disease is Zika virus infectious disease.