GRM5 and alcohol abuse: In conclusion, our study provides clinical evidence for the implication of mGluR5 in the amygdala, OFC and ACC in alcohol use disorder.3,4, Our findings strengthen the case for mGluR5-targeted pharmacological treatment of alcohol use disorder.5,7–9,44 mGluR5 NAMs have shown promising results in preclinical addiction models.7 Partial mGluR5 NAMs also show promising results and are currently in development.45,46, The present study suggests that these pharmacological agents may be helpful in the treatment of alcohol use disorder.5