These genes, which contain binding sites for both MRTF–SRF and YAP–TEAD, include several commonly used as model YAP–TEAD targets, including Cyr61, Ctgf, and Ankrd1. In line with our finding that YAP activity and MRTF activity are mutually dependent, we note that both MRTF–SRF and YAP–TEAD signatures defined here are significantly enriched in activated stromal gene expression signatures in both mouse tumor models and human breast, oral, and pancreatic cancers (Farmer et al. 2009; Lim et al. 2011; Moffitt et al. 2015; Ohlund et al. 2017). Here, CCN2 is linked to familial pancreatic carcinoma.