A Crohn's disease‐associated point mutation T300A is located near the C‐terminal domain of ATG16L1 and has been implicated in affecting autophagic processes, including one dependent on the WD40 CTD (Kuballa et al, 2008; Lassen et al, 2014; Boada‐Romero et al, 2016). This evidence concerns the gene ATG16L1 and Crohn disease.