EZH2 and hepatocellular carcinoma: We mined publicly available clinical tumor expression datasets [R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl)] and noted that the transcript levels of the miR-22 host gene (MIR22HG) were inversely correlated with the expression levels of EZH2 in 90 well-established HCC specimens (Fig. 4a).