LGALS9 and hepatocellular carcinoma: It isalso believed that galectin-9 displaysdichotomousbehavior in HCC, asgalectin-9 down-regulation in hepatocytes promotes tumor growth and metastasis whereas galectin-9 overexpression in Kupffer cells and endothelial cells inhibits the anti-tumor immune responseby inducing T cell apoptosis or senescence [9, 30, 39, 40].