Interestingly, a recent report showed that BDNF is an important determinant of induced pluripotent steam cell (iPSC) differentiation into POMC neurons [52], which suggests that BDNF could play an important role in the putative recovery of the damaged hypothalamus during body mass loss, in the treatment of obesity. This evidence concerns the gene POMC and obesity due to melanocortin 4 receptor deficiency.