Further, SCA subtypes caused by expansions in non-coding regions of genes responsible for SCA8, SCA10, SCA12 and SCA36 as well as other ataxias known to be associated with repeat expansions such as fragile X-associated tremor ataxia syndrome (FXTAS) should be taken into account before applying NGS-based diagnostics. Here, NOP56 is linked to fragile X-associated tremor/ataxia syndrome.