It has been hypothesized that the combination of high leptin, peptide YY and neuropeptide Y together with decreased ghrelin would predispose to hypertension, impaired vasodilation and cardiac hypertrophy [438], although the decrease of renin and aldosterone mentioned above [473] may cast some doubts on the contribution of peptide YY into this. The gene discussed is PYY; the disease is hypertensive disorder.