Along these lines: (i) IFN-γ blockade with fontolizumab, an IFN-γ-neutralizing antibody, has shown minimal beneficial effects in treating psoriatic patients, with limited impact on gene expression and modest histological changes [129]; (ii) IL-12 and IFN-γ expression was not reduced when psoriasis was cleared through IL-23 inhibition [147]. This evidence concerns the gene IFNG and psoriasis.