IFNG and psoriasis: The ability of IFN-γ to promote inflammation in psoriasis was underlined by a seminal study demonstrating that a single intradermal injection of IFN-γ in clinically unaffected skin of both psoriasis patients with mild disease (<10% BSA) and healthy volunteers, induces a transcriptomic signature and cellular infiltration pattern, similar to lesional psoriatic skin [138].