CD4 and psoriasis: Its pathogenic relevance has been strengthened by the identification of LL37-specific autoreactive T cells, belonging to both CD4+ and CD8+ T-cell compartments, that were found in 46% of psoriasis patients and even more frequently in moderate-to-severe psoriasis patients [in up to 75% of patients with Psoriasis Activity Severity Index (PASI) > 10] [146].