FLT3 and acute myeloid leukemia: Sorafenib is also a potent FLT3 inhibitor that led to a marked reduction in bone marrow and peripheral blood blasts in all patients with FLT3 mutations who were involved in a phase I study using sorafenib as a single agent against refractory or relapsed AML, while there was no DLT after oral administration with 200 to 400 mg twice daily [38].