On the contrary, when DIM was co-treated with E2 or CYP, DIM withdrew E2 and CYP-induced cell viability, EMT, migration, and invasion of Ishikawa endometrial cancer cells, even at the low concentration of 10−7 M. This effect of co-treatment of DIM was similar to that of co-treatment of ICI 182,780 with E2 or CYP, indicating that DIM, as a phytoestrogen, has an anti-estrogenic activity that is associated with its anti-metastatic potential to suppress E2 or CYP-induced metastasis of estrogen-dependent endometrial cancer. Here, PPIG is linked to endometrial cancer.