Rosiglitazone, one of the thiazolidinediones, can inhibit metastasis in a murine model of hepatocellular carcinoma [31] and inhibit pancreatic cancer cell invasion and metastasis by regulating MMP-2 expression through phosphatase and tensin homolog (PTEN) [32]. The gene discussed is MMP2; the disease is familial pancreatic carcinoma.