Consistent with our present finding, Galiano et al. [34] demonstrated that SDF-1α and VEGF local therapy in db/db mice enhanced neovascularization at the wound site through a stimulation of local angiogenesis, thus suggesting that SDF-1α or VEGF may be used to promote tissue repair in a wide variety of acute and chronic injuries, particularly in conditions like diabetes or aging [35]. The gene discussed is CXCL12; the disease is diabetes mellitus.