Corrado et al. [100] showed that CML cells release nanovesicles (exosomes) loaded with interleukin 8 (IL-8) which promotes the proliferation and survival of leukemia cells in vitro and in vivo, using a xenograft CML tumor model. The gene discussed is CXCL8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.