ABCB1 and chronic myelogenous leukemia, BCR-ABL1 positive: In relation to Pgp, using the CML K562 cell line and its ABCB1 overexpressing variant K562-dox in the presence of cyclosporine and pantoprazole (both Pgp inhibitors), there was no difference in the intracellular uptake and retention of ponatinib between the two cell lines.