In relation to Pgp, using the CML K562 cell line and its ABCB1 overexpressing variant K562-dox in the presence of cyclosporine and pantoprazole (both Pgp inhibitors), there was no difference in the intracellular uptake and retention of ponatinib between the two cell lines. This evidence concerns the gene PGP and chronic myelogenous leukemia, BCR-ABL1 positive.