Our observation of increased BAG3 levels in DMD myoblasts associated with a detection of more numerous BAG3/HSPB8 complexes in DMD cells fit with these observations and allow us to report for the first time the existence of a BAG1 to BAG3 switch between control and DMD myoblastic cell lines, which suggest a shift to autophagy as a preferential protein degradation pathway. Here, HSPB8 is linked to Duchenne muscular dystrophy.