As for the proteasome, an increase of its expression, of ubiquitin conjugation to muscle proteins, of transcripts encoding ubiquitin, of Ub-conjugating enzymes (E2) and of Ub-ligases (MURF1 and MAFBx/Atrogin-1) were reported to be associated with muscular dystrophies or atrophy [46,47], while deletion of the proteasome component Rpt3 was described to contribute to myofiber degeneration [48]. The gene discussed is PSMC4; the disease is Atrophy.