In conclusion, our results indicate that the refolding capacity of DMD cell lines is not altered; however, the expression of HSPB5 and HSPB8 holdases is modulated, these proteins being preferentially redirected to protein aggregates; this observation might suggest that the chaperone network in DMD myoblasts is harnessed but overwhelmed. Here, CRYAB is linked to Duchenne muscular dystrophy.