In addition, abnormalities of some HSPB members are involved in muscle disorders: HSPB5 mutations are associated with myofibrillar myopathies [61] and HSPB1 or HSPB8 to distal myopathy and Charcot–Mary–Tooth disease type 2 [62,63]. This evidence concerns the gene HSPB1 and distal myopathy.