UGT2B15 and cancer: Elucidating the genetic and environmental regulation of UGT2B15 and 2B17 can be useful for predicting susceptibility to cancer and adverse drug reactions, but more work on the precise mechanisms of UGT2B15 methylation, the interplay of methylation and SNPs, as well as the effects on drug and hormone handling in vivo are needed to tease out the clinical significance of these findings.