Its activation occurs not only downstream of all members of the IL-6 family of cytokines, but also of a great number of other cytokines, growth factors, and oncogenes, including leptin, IL-12, Interferons, IL-10, G-CSF, and Src [51], and of many cytokines that are involved in the pathogenesis of psoriasis, such as IL-21 [52,53,54], IL-22 [46,55,56], IL-23 [57,58], IL-26, and IL-29 [46,59]. This evidence concerns the gene IFNL1 and psoriasis.