Free LDM at the maximum tolerated dosages of 0.045 mg·kg−1 inhibited tumor growth by 56.73%, while anti‐CD30‐LDM at dosages of 0.5, 0.6, 0.7 mg·kg−1 resulted in 61.58%, 75.47%, 87.76% inhibition, respectively. Here, TNFRSF8 is linked to neoplasm.