Furthermore, in a human xenograft model, dual inhibition of Wnt with ICG‐001 and YAP with simvastatin effectively attenuated both mesenchymal and epithelial TNBC tumor burden, diminished both CD44high/CD24−/low and ALDH+ CSC subpopulations, and reduced tumorigenicity after secondary transplantation. Here, YAP1 is linked to neoplasm.