This finding, combined with the previous demonstration that FOXG1 promotes cancer stem‐like cell maintenance in GBM (Verginelli et al., 2013), raises the possibility that FOXG1:TLE1‐mediated transcription repression mechanisms may act to prevent transition of GBM stem‐like cells towards a more differentiated, ‘glioblast‐like’, state associated with enhanced migratory behaviour. This evidence concerns the gene TLE1 and cancer.