The results of these studies provide the first comprehensive genomewide map of FOXG1 and TLE1 targets in GBM cells and identify the gene cation transport regulator‐like protein 1 (CHAC1), a negative regulator of NOTCH signalling and a mediator of apoptosis, as a FOXG1:TLE1 target in GBM. Here, CHAC1 is linked to glioblastoma.