The possibility that transcriptional programs controlled by FOXG1:TLE1 complexes may act to repress genes that negatively regulate NOTCH signalling in GBM, thereby contributing to maintenance of activated NOTCH pathways, is also consistent with the present identification of GATA3 as another FOXG1:TLE1 transcription repression target in GBM. Here, TLE1 is linked to glioblastoma.