GDF15 and central nervous system cancer: We also identified as targets of FOXG1:TLE1 transcriptional repression a number of genes previously proposed to promote glioma invasion, including EGR1, EGR2, GDF15, SERPINE1 and SRPX2 (Codó et al., 2016; Han et al., 2014; Tang et al., 2016; Yukinaga et al., 2014).