2013). Furthermore, it has been shown that dampening down the immune response during Burkholderia spp., infection can increase survival. Inhibition of IL‐1beta, COX‐2 and HMGB1 has been shown to be beneficial in models of melioidosis (Ceballos‐Olvera et al. 2011; Asakrah et al. 2013; Charoensup et al. 2014; Laws et al. 2015). This evidence concerns the gene HMGB1 and infection.