Oxidized oxysterols, enriched in RA synovial fluid, can bind to the transcription factor liver X receptor (LXRα) in synovial macrophages and enhance damage‐associated molecular patterns (DAMPs)‐induced TNF, IL‐6, IL‐1β and granulocyte–macrophage colony‐stimulating factor (G‐CSF) production 25. The gene discussed is IL1B; the disease is rheumatoid arthritis.