GAS6 and rheumatoid arthritis: Axl–/– mice have DCs with an activated phenotype, and develop increasing serum titres of autoantibodies resembling the early breach‐of‐tolerance to self‐antigen characteristic of preclinical phase RA 59, while GAS6–/– mice develop a spontaneous increase in effector Th17 over Tregs that leads to gut inflammation 60.