The SOX10 phosphorylated residues S24, S45 and T240 were selected for further evaluation with respect to DNA binding, transactivation, subcellular localization, and stability because they reside within WW binding domains, which are predicted targets of proline-directed kinases such as MAP kinases and cyclin-dependent kinases [70], both critical pathways for melanoma proliferation and progression. This evidence concerns the gene SOX10 and melanoma.