Five of these SNPs demonstrated the opposite direction of allelic effect between FTD and the immune-mediated diseases (Table 2): (1) rs9261536, nearest gene = TRIM15; (2) rs3094138, nearest gene = TRIM26; (3) rs9268877, nearest gene = HLA-DRA; (4) rs10484561, nearest gene = HLA-DQB1; and (5) rs2269423, nearest gene = AGPAT1. Of the remaining 16, 2 SNPs showed strong linkage disequilibrium (LD), suggesting that they reflected the same signal: rs204991 and rs204989 (nearest gene: GPSM3; pairwise D′ = 1, r2 = 1). The gene discussed is GPSM3; the disease is frontotemporal dementia.