Beyond the HLA region, by leveraging statistical power from large immune-mediated GWASs, we detected novel candidate FTD associations requiring validation within LRRK2, TBKBP1, and PGBD5. Considered together, these findings suggest that various microglia and inflammation-associated genes, particularly within the HLA region, may play a critical and selective role in FTD pathogenesis. Here, PGBD5 is linked to frontotemporal dementia.