IL6 and neoplasm: Numerous data have indicated a positive feedback between NF-κB activation and inflammatory signaling that favors tumor development, such as the up-regulation of cyclooxigenase (COX)-2; nitric oxide synthase (NOS); inflammatory cytokines, such as IL-6, IL-8, and TNF-α; and, chemokines, such as CCL2 and CXCL8 [9,69].