For example, EBV infection is related to Hodgkin’s lymphoma because EBV-encoded latent membrane protein 1 (LMP1), an integral membrane protein, activates both canonical and non-canonical signaling of NF-κB by inducing p100 processing to p52, similar to CD40, BAFFR, and Lymphotoxin receptor (LTR) [87,88,89,90]. The gene discussed is NFKB1; the disease is Hodgkins lymphoma.