CYP2R1 and colorectal cancer: However, for colorectal cancer, two SNPs, rs12794714 (CYP2R1) and rs10741657 (CYP2R1) had nominally significant associations (HR (95% CI), p-values-rs12794714: 1.21 (1.03–1.41), p = 0.02 and rs10741657: 1.22 (1.05–1.43), p = 0.01).