Apart from the lifestyle and environmental factors, MetS can develop as a result of genetic predisposition, which can be related to the polymorphic forms of genes that play an important part in the expression of MetS components, namely: PPAR-γ, FTO and MC4R. Our study provided evidence for the relationships between the A/A genotype of the FTO rs9939609 polymorphism and hyperglycemia, and between the C/C genotype of the PPAR-γ rs1801282 polymorphism and higher blood pressure. This evidence concerns the gene MC4R and metabolic syndrome.