Thus, the APRIL and IL‐10 plasma levels as well as the proportion of CD4+ and CD8+ T cells expressing TACI might reflect the acute phase of P. vivax malaria, and may contribute to calcium‐dependent constitutive activation of nuclear factor of activated T cells (NF‐AT) 84 as observed in the early stage of many infectious diseases 85, 86. This evidence concerns the gene CD8A and infectious disease.