Since IL‐10 upregulates APRIL and BAFF production and secretion 28, 66, 67 and IL‐10 levels correlated positively with parasitaemia, one could speculate that malaria parasites induce an increase of IL‐10 production, which might contribute to the upregulation of APRIL and/or BAFF productions in both infections. The gene discussed is TNFSF13B; the disease is infection.