TRERF1 and persistent truncus arteriosus: As shown in Table 1, chronic pressure overload remarkably induced left ventricular hypertrophy manifested by increased diastolic posterior wall thickness, while rapamycin therapy markedly diminished diastolic posterior wall thickness (0.95 ± 0.09 in TAC+ Vehicle group versus 0.75 ± 0.06 in TAC+ RAPA group, P < 0.05, Table 1).