TWIST1 and renal fibrosis: 51 found that EMT induced tubular epithelia cell cycle arrest in the G2 phase. They also found that transgenic expression of Twist1 prolonged TGF‐β1‐induced G2 arrest, limiting cellular repair and regeneration. Furthermore, In UUO‐induced renal fibrosis, Twist1 deletion in proximal tubular epithelia cells inhibited the EMT process and maintained the integrity of the cells and restored cell proliferation and the repair and regeneration of kidney parenchyma, ultimately alleviating renal interstitial fibrosis 51.