Further, the EWS-FLI1 translocation was reported to be sufficient for increased sensitivity of cells to olaparib, while transient depletion of EWS-FLI1 from Ewing’s sarcoma cells resulted in partial rescue of olaparib sensitivity, suggesting the sensitivity of Ewing’s sarcoma cells to olaparib might be related to EWS-FLI1 transcriptional activity. The gene discussed is EWSR1; the disease is Ewing sarcoma.