Subsequent work by other researchers also explored the role of c-Myc in cancer cells. In 2013 the present author reported that c-Myc can induce and amplify the transcription of some 447 previously reported target genes in a dose-dependent manner (Schuhmacher and Eick, 2013), and in 2014 two independent groups reported that c-Myc can repress active genes and, moreover, that the amplification effect it exerts on all genes is the result of it up-regulating a specific set of target genes (Sabò et al., 2014; Walz et al., 2014; see also Dang, 2014). Here, MYC is linked to cancer.