NRFA and PRFA polymers complexed with the pEF‐TRAIL showed a modest, but statistically significant decrease in MDA‐MB‐231 and UMUC3 cancer cell viability compared to polymers complexed with the EGFP plasmid (Figure 6); approximately ∼30–40% death of cancer cells was seen under these conditions. This evidence concerns the gene TNFSF10 and cancer.