TRAIL is a protein that has been shown to induce programed cell death in cancer cells with minimal effect on normal cells, which makes it an attractive therapeutic for cancer diseases.46, 54, 55 TRAIL induces death in cancer cells by engaging the cellular apoptosis machinery following binding to death receptors DR4 and DR5.55 Folate‐conjugated, aminoglycoside‐derived polymers were employed to deliver a newly constructed plasmid designed to express the TRAIL protein. The gene discussed is TNFRSF10B; the disease is cancer.